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Methamphetamine Induces TET1- and TET3-Dependent DNA Hydroxymethylation of Crh and Avp Genes in the Rat Nucleus Accumbens

Methamphetamine (METH) addiction is a biopsychosocial disorder that is accompanied by multiple relapses even after prolonged abstinence, suggesting the possibilities of long-lasting maladaptive epigenetic changes in the brain. Here, we show that METH administration produced time-dependent increases...

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Detalles Bibliográficos
Autores principales: Jayanthi, Subramaniam, Gonzalez, Betina, McCoy, Michael T., Ladenheim, Bruce, Bisagno, Veronica, Cadet, Jean Lud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948251/
https://www.ncbi.nlm.nih.gov/pubmed/28842817
http://dx.doi.org/10.1007/s12035-017-0750-9