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NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation
BACKGROUND: Systemic inflammation associated with sepsis can induce neuronal hyperexcitability, leading to enhanced seizure predisposition and occurrence. Brain microglia are rapidly activated in response to systemic inflammation and, in this activated state, release multiple cytokines and signaling...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948699/ https://www.ncbi.nlm.nih.gov/pubmed/29753328 http://dx.doi.org/10.1186/s12974-018-1186-5 |