Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

BACKGROUND: Intraneuronal α-synuclein (α-Syn) aggregates known as Lewy bodies (LBs) and the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the pathological hallmarks of Parkinson’s disease (PD). Braak’s hypothesis based on autopsy studies suggests that Lewy pathology i...

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Detalles Bibliográficos
Autores principales: Uemura, Norihito, Yagi, Hisashi, Uemura, Maiko T., Hatanaka, Yusuke, Yamakado, Hodaka, Takahashi, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948849/
https://www.ncbi.nlm.nih.gov/pubmed/29751824
http://dx.doi.org/10.1186/s13024-018-0257-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948849/
https://www.ncbi.nlm.nih.gov/pubmed/29751824
http://dx.doi.org/10.1186/s13024-018-0257-5

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