Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes

The function of medullary thymic epithelial cells (mTECs) is associated with thymocyte adhesion, which is crucial for the negative selection of autoreactive thymocytes in the thymus. This process represents the root of central tolerance of self-components and prevents the onset of autoimmune disease...

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Detalles Bibliográficos
Autores principales: Speck-Hernandez, Cesar A., Assis, Amanda F., Felicio, Rafaela F., Cotrim-Sousa, Larissa, Pezzi, Nicole, Lopes, Gabriel S., Bombonato-Prado, Karina F., Giuliatti, Silvana, Passos, Geraldo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949327/
https://www.ncbi.nlm.nih.gov/pubmed/29867946
http://dx.doi.org/10.3389/fimmu.2018.00964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949327/
https://www.ncbi.nlm.nih.gov/pubmed/29867946
http://dx.doi.org/10.3389/fimmu.2018.00964

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