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The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes
Separase, a known oncogene, is widely overexpressed in numerous human tumors of breast, bone, brain, blood, and prostate. Separase is an emerging target for cancer therapy, and separase enzymatic inhibitors such as sepin-1 are currently being developed to treat separase-overexpressed tumors. Drug me...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949348/ https://www.ncbi.nlm.nih.gov/pubmed/29867452 http://dx.doi.org/10.3389/fphar.2018.00313 |