NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients

The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. Among 87 enrolled patients, 23 (26.4%) had leukopenia. The NUDT15 R139C variant was associated with leukop...

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Detalles Bibliográficos
Autores principales: Fei, Xiang, Shu, Qing, Zhu, Huaijun, Hua, Bingzhu, Wang, Shiying, Guo, Ling, Fang, Yun, Ge, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949564/
https://www.ncbi.nlm.nih.gov/pubmed/29867468
http://dx.doi.org/10.3389/fphar.2018.00460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949564/
https://www.ncbi.nlm.nih.gov/pubmed/29867468
http://dx.doi.org/10.3389/fphar.2018.00460

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