Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability

Double cyclization of short linear peptides obtained by solid phase peptide synthesis was used to prepare bridged bicyclic peptides (BBPs) corresponding to the topology of bridged bicyclic alkanes such as norbornane. Diastereomeric norbornapeptides were investigated by (1)H-NMR, X-ray crystallograph...

Descripción completa

Detalles Bibliográficos
Autores principales: Bartoloni, Marco, Jin, Xian, Marcaida, Maria José, Banha, João, Dibonaventura, Ivan, Bongoni, Swathi, Bartho, Kathrin, Gräbner, Olivia, Sefkow, Michael, Darbre, Tamis, Reymond, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949603/
https://www.ncbi.nlm.nih.gov/pubmed/29861888
http://dx.doi.org/10.1039/c5sc01699a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949603/
https://www.ncbi.nlm.nih.gov/pubmed/29861888
http://dx.doi.org/10.1039/c5sc01699a

Ejemplares similares