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Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability
Double cyclization of short linear peptides obtained by solid phase peptide synthesis was used to prepare bridged bicyclic peptides (BBPs) corresponding to the topology of bridged bicyclic alkanes such as norbornane. Diastereomeric norbornapeptides were investigated by (1)H-NMR, X-ray crystallograph...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949603/ https://www.ncbi.nlm.nih.gov/pubmed/29861888 http://dx.doi.org/10.1039/c5sc01699a |