Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells

BACKGROUND: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it promotes proliferation as well as survival and is considered a proangiogenic factor. Metformin, a drug co...

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Detalles Bibliográficos
Autores principales: Garrido, Maritza P., Vera, Carolina, Vega, Margarita, Quest, Andrew F.G., Romero, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949935/
https://www.ncbi.nlm.nih.gov/pubmed/29774060
http://dx.doi.org/10.1177/1758835918770984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949935/
https://www.ncbi.nlm.nih.gov/pubmed/29774060
http://dx.doi.org/10.1177/1758835918770984

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