Advantages of evaluating γH2AX induction in non-clinical drug development

γH2AX, the phosphorylated form of a histone variant H2AX at Ser 139, is already widely used as a biomarker to research the fundamental biology of DNA damage and repair and to assess the risk of environmental chemicals, pollutants, radiation, and so on. It is also beginning to be used in the early no...

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Detalles Bibliográficos
Autores principales: Motoyama, Shigeki, Takeiri, Akira, Tanaka, Kenji, Harada, Asako, Matsuzaki, Kaori, Taketo, Junko, Matsuo, Saori, Fujii, Etsuko, Mishima, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950202/
https://www.ncbi.nlm.nih.gov/pubmed/29785231
http://dx.doi.org/10.1186/s41021-018-0098-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950202/
https://www.ncbi.nlm.nih.gov/pubmed/29785231
http://dx.doi.org/10.1186/s41021-018-0098-z

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