PIASy antagonizes Ras-driven NSCLC survival by promoting GATA2 SUMOylation

GATA2 regulated transcriptional network has been validated requisite for RAS oncogene-driven non-small cell lung cancer (NSCLC). GATA2 has been reported as a SUMOylated protein. In endothelial cells, its transcriptional activity is attenuated by SUMO-2 conjugation, which is specifically catalyzed by...

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Detalles Bibliográficos
Autores principales: Chen, Bin, Luo, Jie, Zhou, Yirui, Xin, Xu, Cai, Rong, Ling, Chunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950599/
https://www.ncbi.nlm.nih.gov/pubmed/29760808
http://dx.doi.org/10.7150/jca.24137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950599/
https://www.ncbi.nlm.nih.gov/pubmed/29760808
http://dx.doi.org/10.7150/jca.24137

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