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Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia

BACKGROUND: The excitatory amino acid domoic acid, a glutamate and kainic acid analog, is the causative agent of amnesic shellfish poisoning in humans. No studies to our knowledge have investigated the potential contribution to short-term neurotoxicity of the brain microglia, a cell type that consti...

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Detalles Bibliográficos
Autores principales: Mayer, Alejandro MS, Hall, Mary, Fay, Michael J, Lamar, Peter, Pearson, Celeste, Prozialeck, Walter C, Lehmann, Virginia KB, Jacobson, Peer B, Romanic, Anne M, Uz, Tolga, Manev, Hari
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59507/
https://www.ncbi.nlm.nih.gov/pubmed/11686853
http://dx.doi.org/10.1186/1471-2210-1-7