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Optimization of the Critical Parameters of the Spherical Agglomeration Crystallization Method by the Application of the Quality by Design Approach

This research work presents the use of the Quality by Design (QbD) concept for optimization of the spherical agglomeration crystallization method in the case of the active agent, ambroxol hydrochloride (AMB HCl). AMB HCl spherical crystals were formulated by the spherical agglomeration method, which...

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Detalles Bibliográficos
Autores principales: Gyulai, Orsolya, Kovács, Anita, Sovány, Tamás, Csóka, Ildikó, Aigner, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951519/
https://www.ncbi.nlm.nih.gov/pubmed/29677152
http://dx.doi.org/10.3390/ma11040635