A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency

The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. One peculiarity is an exposed hydrophobic loop in the toxin’s cell binding domai...

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Detalles Bibliográficos
Autores principales: Stern, Daniel, Weisemann, Jasmin, Le Blanc, Alexander, von Berg, Laura, Mahrhold, Stefan, Piesker, Janett, Laue, Michael, Luppa, Peter B., Dorner, Martin Bernhard, Dorner, Brigitte Gertrud, Rummel, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951583/
https://www.ncbi.nlm.nih.gov/pubmed/29718991
http://dx.doi.org/10.1371/journal.ppat.1007048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951583/
https://www.ncbi.nlm.nih.gov/pubmed/29718991
http://dx.doi.org/10.1371/journal.ppat.1007048

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