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CO(2)-sensitive tRNA modification associated with human mitochondrial disease
It has been generally thought that tRNA modifications are stable and static, and their frequencies are rarely regulated. N(6)-threonylcarbamoyladenosine (t(6)A) occurs at position 37 of five mitochondrial (mt-)tRNA species. We show that YRDC and OSGEPL1 are responsible for t(6)A37 formation, utilizi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951830/ https://www.ncbi.nlm.nih.gov/pubmed/29760464 http://dx.doi.org/10.1038/s41467-018-04250-4 |