Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma

Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominates in 10/32 samples, w...

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Detalles Bibliográficos
Autores principales: North, Jeffrey P., Golovato, Justin, Vaske, Charles J., Sanborn, J. Zachary, Nguyen, Andrew, Wu, Wei, Goode, Benjamin, Stevers, Meredith, McMullen, Kevin, Perez White, Bethany E., Collisson, Eric A., Bloomer, Michele, Solomon, David A., Benz, Stephen C., Cho, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951856/
https://www.ncbi.nlm.nih.gov/pubmed/29760388
http://dx.doi.org/10.1038/s41467-018-04008-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951856/
https://www.ncbi.nlm.nih.gov/pubmed/29760388
http://dx.doi.org/10.1038/s41467-018-04008-y

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