Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue

Sustained spindle tension applied to sister centromeres during mitosis eventually leads to uncoordinated loss of sister chromatid cohesion, a phenomenon known as “cohesion fatigue.” We report that Aurora A-dependent phosphorylation of serine 7 of the centromere histone variant CENP-A (p-CENP-AS7) pr...

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Detalles Bibliográficos
Autores principales: Eot-Houllier, Grégory, Magnaghi-Jaulin, Laura, Fulcrand, Géraldine, Moyroud, François-Xavier, Monier, Solange, Jaulin, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951908/
https://www.ncbi.nlm.nih.gov/pubmed/29760389
http://dx.doi.org/10.1038/s41467-018-04089-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951908/
https://www.ncbi.nlm.nih.gov/pubmed/29760389
http://dx.doi.org/10.1038/s41467-018-04089-9

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