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Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue
Sustained spindle tension applied to sister centromeres during mitosis eventually leads to uncoordinated loss of sister chromatid cohesion, a phenomenon known as “cohesion fatigue.” We report that Aurora A-dependent phosphorylation of serine 7 of the centromere histone variant CENP-A (p-CENP-AS7) pr...
Autores principales: | Eot-Houllier, Grégory, Magnaghi-Jaulin, Laura, Fulcrand, Géraldine, Moyroud, François-Xavier, Monier, Solange, Jaulin, Christian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951908/ https://www.ncbi.nlm.nih.gov/pubmed/29760389 http://dx.doi.org/10.1038/s41467-018-04089-9 |
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