Alzheimer’s Transgenic Model Is Characterized by Very Early Brain Network Alterations and β-CTF Fragment Accumulation: Reversal by β-Secretase Inhibition

Alzheimer’s disease (AD) is defined by the presence of amyloid-β (Aβ) and tau protein aggregates. However, increasing data is suggesting that brain network alterations rather than protein deposition could account for the early pathogenesis of the disease. In the present study, we performed in vitro...

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Detalles Bibliográficos
Autores principales: Mondragón-Rodríguez, Siddhartha, Gu, Ning, Manseau, Frederic, Williams, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952042/
https://www.ncbi.nlm.nih.gov/pubmed/29867356
http://dx.doi.org/10.3389/fncel.2018.00121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952042/
https://www.ncbi.nlm.nih.gov/pubmed/29867356
http://dx.doi.org/10.3389/fncel.2018.00121

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