Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation

Sinomenine, a bioactive alkaloid isolated from the traditional Chinese herb Sinomenium acutum, possesses antiinflammatory, antinociceptive, antifibrotic, and antitumorigenic properties. In this work, we sought to explore the biological effects of sinomenine on glioma cells. It was found that sinomen...

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Detalles Bibliográficos
Autores principales: He, Xiaoyan, Maimaiti, Mayinur, Jiao, Yan, Meng, Xuegang, Li, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952277/
https://www.ncbi.nlm.nih.gov/pubmed/29756546
http://dx.doi.org/10.1177/1533034618770305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952277/
https://www.ncbi.nlm.nih.gov/pubmed/29756546
http://dx.doi.org/10.1177/1533034618770305

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