Cargando…

Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation

Sinomenine, a bioactive alkaloid isolated from the traditional Chinese herb Sinomenium acutum, possesses antiinflammatory, antinociceptive, antifibrotic, and antitumorigenic properties. In this work, we sought to explore the biological effects of sinomenine on glioma cells. It was found that sinomen...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Xiaoyan, Maimaiti, Mayinur, Jiao, Yan, Meng, Xuegang, Li, Hongyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952277/ https://www.ncbi.nlm.nih.gov/pubmed/29756546 http://dx.doi.org/10.1177/1533034618770305

Ejemplares similares

Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression
por: Liu, Zhen, et al.
Publicado: (2014)

Sinomenine Inhibits the Progression of Bladder Cancer Cells by Downregulating LncRNA-HEIH Expression
por: Xu, Haili, et al.
Publicado: (2021)

Retraction: Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression
por: Liu, Zhen, et al.
Publicado: (2019)

Sinomenine Inhibits Non-Small Cell Lung Cancer via Downregulation of Hexokinases II-Mediated Aerobic Glycolysis
por: Liu, Wenbin, et al.
Publicado: (2020)

Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance
por: Huang, Xiao-Yan, et al.
Publicado: (2022)

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors
por: Schmid, Nina, et al.
Publicado: (2021)

Sirtuin 1 alleviates alcoholic liver disease by inhibiting HMGB1 acetylation and translocation
por: Fu, Juan, et al.
Publicado: (2023)

Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs
por: Shen, Kun-Hung, et al.
Publicado: (2020)

Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death
por: Sun, Yue, et al.
Publicado: (2022)

p53-dependent growth arrest and induction of p21: A critical role for PCAF-mediated histone acetylation
por: Eckner, Richard
Publicado: (2012)

Agranulocytosis Induced by Sinomenine Hydrochloride
por: Chen, Juerong, et al.
Publicado: (2017)

Sinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1
por: Qu, Xiaoyan, et al.
Publicado: (2021)

Anti-breast cancer sinomenine derivatives via mechanisms of apoptosis induction and metastasis reduction
por: Gao, Xiang, et al.
Publicado: (2022)

Effect of sinomenine hydrochloride on radiosensitivity of esophageal squamous cell carcinoma cells
por: Fu, Shenbo, et al.
Publicado: (2018)

Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract
por: Zhang, Mao-Fan, et al.
Publicado: (2014)

Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
por: Lee, Hyesung, et al.
Publicado: (2021)

Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells
por: Yoon, Kyoung B., et al.
Publicado: (2016)

Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1
por: Guan, Jingqian, et al.
Publicado: (2020)

Sinomenine hydrochloride inhibits cell survival in human hepatoma Huh7 cells
por: Wang, Ying, et al.
Publicado: (2018)

Sinomenine Relieves Airway Remodeling By Inhibiting Epithelial-Mesenchymal Transition Through Downregulating TGF-β1 and Smad3 Expression In Vitro and In Vivo
por: He, Hongjuan, et al.
Publicado: (2021)

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
por: Kong, Li Ren, et al.
Publicado: (2020)

Sinomenine sensitizes gastric cancer cells to 5-fluorouracil in vitro and in vivo
por: LIAO, FEI, et al.
Publicado: (2013)

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression
por: Lee, Ok-Hee, et al.
Publicado: (2020)

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin
por: Velásquez, Douglas A., et al.
Publicado: (2011)

Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
por: Nishida, Seiichiro, et al.
Publicado: (2007)

Determination of Sinomenine in Cubosome Nanoparticles by HPLC Technique
por: Zhou, Yanfang, et al.
Publicado: (2015)

Analgesic Mechanism of Sinomenine against Chronic Pain
por: Jiang, Wei, et al.
Publicado: (2020)

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells
por: Park, Hye Young, et al.
Publicado: (2017)

Oncometabolic role of mitochondrial sirtuins in glioma patients
por: Haq, Maria Fazal Ul, et al.
Publicado: (2023)

Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity
por: Chao, Sung-Chuan, et al.
Publicado: (2017)

Intermedin(1-53) attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1
por: Chen, Yao, et al.
Publicado: (2020)

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43
por: Garcia Morato, Jorge, et al.
Publicado: (2022)

Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1
por: Siegel, David, et al.
Publicado: (2022)

Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells
por: Zhao, Aomei, et al.
Publicado: (2021)

Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue
por: Gao, Tianle, et al.
Publicado: (2019)

Sophisticated Framework between Cell Cycle Arrest and Apoptosis Induction Based on p53 Dynamics
por: Hamada, Hiroyuki, et al.
Publicado: (2009)

Period2 downregulation inhibits glioma cell apoptosis by activating the MDM2-TP53 pathway
por: Zhanfeng, Niu, et al.
Publicado: (2016)

Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis
por: Zhang, Yu, et al.
Publicado: (2021)

Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets
por: Liu, Weiwei, et al.
Publicado: (2018)

The anti-tumor potential of sinomenine: a narrative review
por: Zhu, Jun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_87opa0sm38ih3cd84e9684djvg