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Functional Characterization of Native, High-Affinity GABA(A) Receptors in Human Pancreatic β Cells

In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABA(A) receptor...

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Detalles Bibliográficos
Autores principales: Korol, Sergiy V., Jin, Zhe, Jin, Yang, Bhandage, Amol K., Tengholm, Anders, Gandasi, Nikhil R., Barg, Sebastian, Espes, Daniel, Carlsson, Per-Ola, Laver, Derek, Birnir, Bryndis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952339/
https://www.ncbi.nlm.nih.gov/pubmed/29606630
http://dx.doi.org/10.1016/j.ebiom.2018.03.014