Cargando…

Functional Characterization of Native, High-Affinity GABA(A) Receptors in Human Pancreatic β Cells

In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABA(A) receptor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Korol, Sergiy V., Jin, Zhe, Jin, Yang, Bhandage, Amol K., Tengholm, Anders, Gandasi, Nikhil R., Barg, Sebastian, Espes, Daniel, Carlsson, Per-Ola, Laver, Derek, Birnir, Bryndis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952339/ https://www.ncbi.nlm.nih.gov/pubmed/29606630 http://dx.doi.org/10.1016/j.ebiom.2018.03.014

Ejemplares similares

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4(+) T Cells and Is Immunosuppressive in Type 1 Diabetes
por: Bhandage, Amol K., et al.
Publicado: (2018)

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in α-Cells
por: Jin, Yang, et al.
Publicado: (2013)

Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
por: Bhandage, Amol K., et al.
Publicado: (2018)

Different Subtypes of GABA-A Receptors Are Expressed in Human, Mouse and Rat T Lymphocytes
por: Mendu, Suresh K., et al.
Publicado: (2012)

Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
por: Bhandage, Amol K., et al.
Publicado: (2019)

Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
por: Babateen, Omar, et al.
Publicado: (2017)

GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
por: Korol, Sergiy V., et al.
Publicado: (2020)

The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA(A) Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
por: Korol, Sergiy V., et al.
Publicado: (2015)

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics
por: Jin, Zhe, et al.
Publicado: (2014)

GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
por: Espes, Daniel, et al.
Publicado: (2021)

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics
por: Bhandage, Amol K., et al.
Publicado: (2014)

GABA is an effective immunomodulatory molecule
por: Jin, Zhe, et al.
Publicado: (2011)

GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
por: Jin, Zhe, et al.
Publicado: (2011)

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
por: Omar-Hmeadi, Muhmmad, et al.
Publicado: (2020)

Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes
por: Hill, Henrik, et al.
Publicado: (2021)

Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics
por: Jin, Zhe, et al.
Publicado: (2014)

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
por: Petrenko, Volodymyr, et al.
Publicado: (2020)

Insulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current
por: Jin, Zhe, et al.
Publicado: (2011)

GABA signalling in human pancreatic islets
por: Jin, Zhe, et al.
Publicado: (2023)

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
por: Guček, Alenka, et al.
Publicado: (2019)

Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
por: Jin, Zhe, et al.
Publicado: (2012)

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
por: Smits, Anja, et al.
Publicado: (2012)

GABA Maintains the Proliferation of Progenitors in the Developing Chick Ciliary Marginal Zone and Non-Pigmented Ciliary Epithelium
por: Ring, Henrik, et al.
Publicado: (2012)

Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic β-cells
por: Braun, Matthias, et al.
Publicado: (2004)

Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
por: Espes, Daniel, et al.
Publicado: (2014)

Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes
por: Espes, Daniel, et al.
Publicado: (2013)

Unsurpassed Intrahepatic Islet Engraftment – the Quest for New Sites for Beta Cell Replacement
por: Liljebäck, Hanna, et al.
Publicado: (2019)

Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
por: Grönberg, Annika, et al.
Publicado: (2020)

Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cells
por: Cortese, Giuliana, et al.
Publicado: (2016)

Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
por: Espes, Daniel, et al.
Publicado: (2011)

Severe diabetic ketoacidosis in combination with starvation and anorexia nervosa at onset of type 1 diabetes: A case report
por: Espes, Daniel, et al.
Publicado: (2013)

Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases
por: Magnusson, Louise, et al.
Publicado: (2020)

Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
por: Grönberg, Annika, et al.
Publicado: (2022)

Irisin—A Pancreatic Islet Hormone
por: Norman, Daniel, et al.
Publicado: (2022)

ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
por: Schuster, Jens, et al.
Publicado: (2022)

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis
por: Gandasi, Nikhil R., et al.
Publicado: (2015)

Syntaxin clusters at secretory granules in a munc18-bound conformation
por: Yin, Peng, et al.
Publicado: (2018)

Quantification of β-Cell Mass in Intramuscular Islet Grafts Using Radiolabeled Exendin-4
por: Espes, Daniel, et al.
Publicado: (2016)

Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
por: Ullsten, Sara, et al.
Publicado: (2020)

Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
por: Espes, Daniel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1a28fad58nstloa958r8tt4kd7