GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4(+) T Cells and Is Immunosuppressive in Type 1 Diabetes

The neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule in the brain and in pancreatic islets. Here, we demonstrate that GABA regulates cytokine secretion from human peripheral blood mononuclear cells (PBMCs) and CD4(+) T cells. In anti-CD3 stimulated PBMCs, GABA (100 ...

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Detalles Bibliográficos
Autores principales: Bhandage, Amol K., Jin, Zhe, Korol, Sergiy V., Shen, Qiujin, Pei, Yu, Deng, Qiaolin, Espes, Daniel, Carlsson, Per-Ola, Kamali-Moghaddam, Masood, Birnir, Bryndis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952354/
https://www.ncbi.nlm.nih.gov/pubmed/29627388
http://dx.doi.org/10.1016/j.ebiom.2018.03.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952354/
https://www.ncbi.nlm.nih.gov/pubmed/29627388
http://dx.doi.org/10.1016/j.ebiom.2018.03.019

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