A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes

Loss of first-phase insulin release is an early pathogenic feature of type 2 diabetes (T2D). Various mouse models exist to study T2D; however, few recapitulate the early β-cell defects seen in humans. We sought to develop a nongenetic mouse model of T2D that exhibits reduced first-phase insulin secr...

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Detalles Bibliográficos
Autores principales: Parilla, Jacqueline H., Willard, Joshua R., Barrow, Breanne M., Zraika, Sakeneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952555/
https://www.ncbi.nlm.nih.gov/pubmed/29854823
http://dx.doi.org/10.1155/2018/6106051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952555/
https://www.ncbi.nlm.nih.gov/pubmed/29854823
http://dx.doi.org/10.1155/2018/6106051

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