Early cysteine-dependent inactivation of 26S proteasomes does not involve particle disassembly

Under oxidative stress 26S proteasomes suffer reversible disassembly into its 20S and 19S subunits, a process mediated by HSP70. This inhibits the degradation of polyubiquitinated proteins by the 26S proteasome and allows the degradation of oxidized proteins by a free 20S proteasome. Low fluxes of a...

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Detalles Bibliográficos
Autores principales: Hugo, Martín, Korovila, Ioanna, Köhler, Markus, García-García, Carlos, Cabrera-García, J. Daniel, Marina, Anabel, Martínez-Ruiz, Antonio, Grune, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952582/
https://www.ncbi.nlm.nih.gov/pubmed/29499565
http://dx.doi.org/10.1016/j.redox.2018.02.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952582/
https://www.ncbi.nlm.nih.gov/pubmed/29499565
http://dx.doi.org/10.1016/j.redox.2018.02.016

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