Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC)

BACKGROUND: Although 5-Flourouracil(5-FU) is used as the first-choice treatment for advanced hepatocellular carcinoma (HCC), it is associated with acquired and intrinsic resistance. Hyperactivation of mTOR signaling has been linked to tumorigenesis and chemoresistance in HCC. The aim of this study w...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Jia, Qing-an, Kadel, Dhruba, Zhang, Xiao-fei, Zhang, Quan-bao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952809/
https://www.ncbi.nlm.nih.gov/pubmed/29720580
http://dx.doi.org/10.12659/MSM.907514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952809/
https://www.ncbi.nlm.nih.gov/pubmed/29720580
http://dx.doi.org/10.12659/MSM.907514

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