Cargando…

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver

p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elucidate the mechanism(s) involved and the age-related...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pérez, Salvador, Rius-Pérez, Sergio, Tormos, Ana M., Finamor, Isabela, Nebreda, Ángel R., Taléns-Visconti, Raquel, Sastre, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952885/ https://www.ncbi.nlm.nih.gov/pubmed/29567616 http://dx.doi.org/10.1016/j.redox.2018.02.017

Ejemplares similares

p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury
por: Rius-Pérez, Sergio, et al.
Publicado: (2019)

p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging
por: Tormos, Ana M., et al.
Publicado: (2017)

Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice
por: Finamor, Isabela, et al.
Publicado: (2017)

Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice
por: Finamor, Isabela A., et al.
Publicado: (2021)

Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
por: Navarrete, Marta, et al.
Publicado: (2019)

Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase
por: Rius-Pérez, Sergio, et al.
Publicado: (2019)

A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling
por: Terriente-Félix, Ana, et al.
Publicado: (2017)

Roles of p38α mitogen‐activated protein kinase in mouse models of inflammatory diseases and cancer
por: Gupta, Jalaj, et al.
Publicado: (2015)

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK
por: Pereira, Lorena, et al.
Publicado: (2013)

Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism
por: Martín-Segura, Adrián, et al.
Publicado: (2019)

Autophagy-induced senescence is regulated by p38α signaling
por: Slobodnyuk, Konstantin, et al.
Publicado: (2019)

PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism
por: Rius-Pérez, Sergio, et al.
Publicado: (2020)

p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3
por: Rius-Pérez, Sergio, et al.
Publicado: (2022)

Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation
por: Rius-Pérez, Sergio, et al.
Publicado: (2023)

Induction of oxidative metabolism by the p38α/MK2 pathway
por: Trempolec, Natalia, et al.
Publicado: (2017)

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors
por: Gupta, Jalaj, et al.
Publicado: (2015)

Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
por: Batlle, Raquel, et al.
Publicado: (2019)

Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α
por: Cubillos-Rojas, Mónica, et al.
Publicado: (2023)

Diversity and versatility of p38 kinase signalling in health and disease
por: Canovas, Begoña, et al.
Publicado: (2021)

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
por: Pous, Joan, et al.
Publicado: (2023)

Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α
por: del Barco Barrantes, Ivan, et al.
Publicado: (2017)

MAPK signaling control of colon cancer metastasis
por: Urosevic, Jelena, et al.
Publicado: (2014)

Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
por: Barker, Katie H., et al.
Publicado: (2022)

Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis
por: Youssif, Catrin, et al.
Publicado: (2018)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Impact of Myeloid p38α/MAPK on Orthodontic Tooth Movement
por: Kirschneck, Christian, et al.
Publicado: (2022)

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition
por: Matesanz, Nuria, et al.
Publicado: (2018)

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner
por: Cong, Qian, et al.
Publicado: (2017)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells
por: Wöll, Stefan, et al.
Publicado: (2007)

p38 MAPK priming boosts VSMC proliferation and arteriogenesis by promoting PGC1α-dependent mitochondrial dynamics
por: Sahún-Español, Álvaro, et al.
Publicado: (2022)

Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective
por: Pérez, Salvador, et al.
Publicado: (2022)

Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice
por: Rius-Pérez, Sergio, et al.
Publicado: (2020)

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations
por: Kuzmanic, Antonija, et al.
Publicado: (2017)

Regulation of myogenic activation of p38 MAPK by TACE-mediated TNFα release
por: Li, Yi-Ping, et al.
Publicado: (2014)

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK
por: Ni, Yawen, et al.
Publicado: (2017)

Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy
por: Yuasa, Kazuki, et al.
Publicado: (2018)

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK
por: Liu, Jie, et al.
Publicado: (2017)

Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus
por: Vielmuth, Franziska, et al.
Publicado: (2018)

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
por: Hu, Ping, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_u2p0vpf3oajs4tokollcjudsci