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The uremic toxin hippurate promotes endothelial dysfunction via the activation of Drp1-mediated mitochondrial fission
The accumulation of uremic toxins in chronic kidney disease (CKD) induces inflammation, oxidative stress and endothelial dysfunction, which is a key step in atherosclerosis. Accumulating evidence indicates increased mitochondrial fission is a contributing mechanism for impaired endothelial function....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953222/ https://www.ncbi.nlm.nih.gov/pubmed/29573704 http://dx.doi.org/10.1016/j.redox.2018.03.010 |