Role of duplicate genes in determining the tissue-selectivity of hereditary diseases

A longstanding puzzle in human genetics is what limits the clinical manifestation of hundreds of hereditary diseases to certain tissues, while their causal genes are expressed throughout the human body. A general conception is that tissue-selective disease phenotypes emerge when masking factors oper...

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Detalles Bibliográficos
Autores principales: Barshir, Ruth, Hekselman, Idan, Shemesh, Netta, Sharon, Moran, Novack, Lena, Yeger-Lotem, Esti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953478/
https://www.ncbi.nlm.nih.gov/pubmed/29723191
http://dx.doi.org/10.1371/journal.pgen.1007327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953478/
https://www.ncbi.nlm.nih.gov/pubmed/29723191
http://dx.doi.org/10.1371/journal.pgen.1007327

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