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Role of duplicate genes in determining the tissue-selectivity of hereditary diseases
A longstanding puzzle in human genetics is what limits the clinical manifestation of hundreds of hereditary diseases to certain tissues, while their causal genes are expressed throughout the human body. A general conception is that tissue-selective disease phenotypes emerge when masking factors oper...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953478/ https://www.ncbi.nlm.nih.gov/pubmed/29723191 http://dx.doi.org/10.1371/journal.pgen.1007327 |