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Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α(+)thalassaemia
Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McC(b), occur at high frequencies, consistent with selection by malaria. Previous studies have been...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953541/ https://www.ncbi.nlm.nih.gov/pubmed/29690995 http://dx.doi.org/10.7554/eLife.31579 |