Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α(+)thalassaemia

Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McC(b), occur at high frequencies, consistent with selection by malaria. Previous studies have been...

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Detalles Bibliográficos
Autores principales: Opi, D Herbert, Swann, Olivia, Macharia, Alexander, Uyoga, Sophie, Band, Gavin, Ndila, Carolyne M, Harrison, Ewen M, Thera, Mahamadou A, Kone, Abdoulaye K, Diallo, Dapa A, Doumbo, Ogobara K, Lyke, Kirsten E, Plowe, Christopher V, Moulds, Joann M, Shebbe, Mohammed, Mturi, Neema, Peshu, Norbert, Maitland, Kathryn, Raza, Ahmed, Kwiatkowski, Dominic P, Rockett, Kirk A, Williams, Thomas N, Rowe, J Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Epidemiology and Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953541/
https://www.ncbi.nlm.nih.gov/pubmed/29690995
http://dx.doi.org/10.7554/eLife.31579

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