B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

B cells provide humoral immunity by differentiating into antibody-secreting plasma cells, a process that requires cellular division and is linked to DNA hypomethylation. Conversely, little is known about how de novo deposition of DNA methylation affects B cell fate and function. Here we show that ge...

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Detalles Bibliográficos
Autores principales: Barwick, Benjamin G., Scharer, Christopher D., Martinez, Ryan J., Price, Madeline J., Wein, Alexander N., Haines, Robert R., Bally, Alexander P. R., Kohlmeier, Jacob E., Boss, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953949/
https://www.ncbi.nlm.nih.gov/pubmed/29765016
http://dx.doi.org/10.1038/s41467-018-04234-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953949/
https://www.ncbi.nlm.nih.gov/pubmed/29765016
http://dx.doi.org/10.1038/s41467-018-04234-4

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