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Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development

Cardiotoxicity is among the top drug safety concerns, and is of specific interest in tuberculosis, where this is a known or potential adverse event of current and emerging treatment regimens. As there is a need for a tool, beyond the QT interval, to quantify cardiotoxicity early in drug development,...

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Detalles Bibliográficos
Autores principales: Polak, Sebastian, Romero, Klaus, Berg, Alexander, Patel, Nikunjkumar, Jamei, Masoud, Hermann, David, Hanna, Debra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953981/
https://www.ncbi.nlm.nih.gov/pubmed/29520534
http://dx.doi.org/10.1007/s10928-018-9580-2