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Oncotically Driven Control over Glycocalyx Dimension for Cell Surface Engineering and Protein Binding in the Longitudinal Direction

Here we present a simple technique for re-directing reactions on the cell surface to the outermost region of the glycocalyx. Macromolecular crowding with inert polymers was utilized to reversibly alter the accessibility of glycocalyx proteoglycans toward cell-surface reactive probes allowing for rea...

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Detalles Bibliográficos
Autores principales: Siren, Erika M. J., Chapanian, Rafi, Constantinescu, Iren, Brooks, Donald E., Kizhakkedathu, Jayachandran N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954099/
https://www.ncbi.nlm.nih.gov/pubmed/29765073
http://dx.doi.org/10.1038/s41598-018-25870-2