Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors

Fenfluramine exhibits antiepileptic properties and thus diminishes epileptiform discharges in experimental animal models of Dravet syndrome. Fenfluramine is metabolized into norfenfluramine in vivo, which shows greater affinity and agonist activity at serotonin 5HT2 receptors (5HT2R) than fenflurami...

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Detalles Bibliográficos
Autores principales: Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar, Garzón, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955088/
https://www.ncbi.nlm.nih.gov/pubmed/29805740
http://dx.doi.org/10.18632/oncotarget.25169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955088/
https://www.ncbi.nlm.nih.gov/pubmed/29805740
http://dx.doi.org/10.18632/oncotarget.25169

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