Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

Juvenile Myelomonocytic Leukemia (JMML) is a pediatric myeloproliferative neoplasm (MPN) that has a poor prognosis. Somatic mutations in Ptpn11 are the most frequent cause of JMML and they commonly occur in utero. Animal models of mutant Ptpn11 have probed the signaling pathways that contribute to J...

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Detalles Bibliográficos
Autores principales: Tarnawsky, Stefan P., Yu, Wen-Mei, Qu, Cheng-Kui, Chan, Rebecca J., Yoder, Mervin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955130/
https://www.ncbi.nlm.nih.gov/pubmed/29774106
http://dx.doi.org/10.18632/oncotarget.25073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955130/
https://www.ncbi.nlm.nih.gov/pubmed/29774106
http://dx.doi.org/10.18632/oncotarget.25073

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