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Vorapaxar treatment reduces mesangial expansion in streptozotocin-induced diabetic nephropathy in mice
BACKGROUND: Twenty years after the onset of diabetes, up to 40% of patients develop diabetic nephropathy. Protease-activated receptor-1 (PAR-1) has recently been shown to aggravate the development of experimental diabetic nephropathy. PAR-1 deficient mice develop less albuminuria and glomerular lesi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955164/ https://www.ncbi.nlm.nih.gov/pubmed/29774092 http://dx.doi.org/10.18632/oncotarget.25069 |