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Rare genetic heterogeneity within single tumor discovered for the first time in colorectal liver metastases after liver resection
Effective individualized treatment of patients with colorectal liver metastases (CLM) requires tumor genotyping, usually based on the analysis of one single sample per patient. Therapy failure may partially be explained by sampling errors and/or intratumoral genetic heterogeneity. We aimed to demons...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955166/ https://www.ncbi.nlm.nih.gov/pubmed/29774112 http://dx.doi.org/10.18632/oncotarget.25119 |