SN38-loaded <100 nm targeted liposomes for improving poor solubility and minimizing burst release and toxicity: in vitro and in vivo study

BACKGROUND: SN38 (7-ethyl-10-hydroxycamptothecin) is a camptothecin derivative acts against various tumors. However, SN38 is hydrolyzed in the physiological environment (pH 7.4), and this instability interferes with its potential therapeutic effect. Our objective was to investigate SN38-loaded lipos...

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Detalles Bibliográficos
Autores principales: Fang, Yi-Ping, Chuang, Chih-Hung, Wu, Yi-Jhun, Lin, Hsin-Che, Lu, Yun-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955381/
https://www.ncbi.nlm.nih.gov/pubmed/29785106
http://dx.doi.org/10.2147/IJN.S158426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955381/
https://www.ncbi.nlm.nih.gov/pubmed/29785106
http://dx.doi.org/10.2147/IJN.S158426

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