SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia

Children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) overexpressing the CRLF2 gene (hiCRLF2) have poor prognosis. CRLF2 protein overexpression leads to activated JAK/STAT signaling and trials are underway using JAK inhibitors to overcome treatment failure. Pre-clinical studies indic...

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Detalles Bibliográficos
Autores principales: Sarno, Jolanda, Savino, Angela M., Buracchi, Chiara, Palmi, Chiara, Pinto, Stefania, Bugarin, Cristina, Jager, Astraea, Bresolin, Silvia, Barber, Ruth C., Silvestri, Daniela, Israeli, Shai, Dyer, Martin J.S., Cazzaniga, Giovanni, Nolan, Garry P., Biondi, Andrea, Davis, Kara L., Gaipa, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955419/
https://www.ncbi.nlm.nih.gov/pubmed/29796158
http://dx.doi.org/10.18632/oncotarget.25089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955419/
https://www.ncbi.nlm.nih.gov/pubmed/29796158
http://dx.doi.org/10.18632/oncotarget.25089

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