High-dimensional single-cell phenotyping reveals extensive haploinsufficiency

Haploinsufficiency, a dominant phenotype caused by a heterozygous loss-of-function mutation, has been rarely observed. However, high-dimensional single-cell phenotyping of yeast morphological characteristics revealed haploinsufficiency phenotypes for more than half of 1,112 essential genes under opt...

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Detalles Bibliográficos
Autores principales: Ohnuki, Shinsuke, Ohya, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955526/
https://www.ncbi.nlm.nih.gov/pubmed/29768403
http://dx.doi.org/10.1371/journal.pbio.2005130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955526/
https://www.ncbi.nlm.nih.gov/pubmed/29768403
http://dx.doi.org/10.1371/journal.pbio.2005130

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