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High-dimensional single-cell phenotyping reveals extensive haploinsufficiency
Haploinsufficiency, a dominant phenotype caused by a heterozygous loss-of-function mutation, has been rarely observed. However, high-dimensional single-cell phenotyping of yeast morphological characteristics revealed haploinsufficiency phenotypes for more than half of 1,112 essential genes under opt...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955526/ https://www.ncbi.nlm.nih.gov/pubmed/29768403 http://dx.doi.org/10.1371/journal.pbio.2005130 |