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Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone

The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that plays an important role in cellular calcium signaling contributing to synaptic development and plasticity, and is a key drug target for the treatment of neurodegenerative conditions such as Alzheimer’s disease. Here w...

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Detalles Bibliográficos
Autores principales: King, Justin R., Kabbani, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955587/
https://www.ncbi.nlm.nih.gov/pubmed/29768467
http://dx.doi.org/10.1371/journal.pone.0197247