How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mes...

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Detalles Bibliográficos
Autores principales: Rehrauer, Hubert, Wu, Licun, Blum, Walter, Pecze, Lazslo, Henzi, Thomas, Serre-Beinier, Véronique, Aquino, Catherine, Vrugt, Bart, de Perrot, Marc, Schwaller, Beat, Felley-Bosco, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955862/
https://www.ncbi.nlm.nih.gov/pubmed/29507420
http://dx.doi.org/10.1038/s41388-018-0153-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955862/
https://www.ncbi.nlm.nih.gov/pubmed/29507420
http://dx.doi.org/10.1038/s41388-018-0153-z

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