USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis

Overexpression of Cyclin E has been seen in many types of cancers. However, the underlying mechanism remains enigmatic. Herein, we identified ubiquitin-specific peptidase 27 (USP27) as a Cyclin E interactor. We found that USP27 promoted Cyclin E stability by negatively regulating its ubiquitination....

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Detalles Bibliográficos
Autores principales: Dong, Ling, Yu, Le, Bai, Chunrong, Liu, Liu, Long, Hua, Shi, Lei, Lin, Zhenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955865/
https://www.ncbi.nlm.nih.gov/pubmed/29497124
http://dx.doi.org/10.1038/s41388-018-0137-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955865/
https://www.ncbi.nlm.nih.gov/pubmed/29497124
http://dx.doi.org/10.1038/s41388-018-0137-z

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