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USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis
Overexpression of Cyclin E has been seen in many types of cancers. However, the underlying mechanism remains enigmatic. Herein, we identified ubiquitin-specific peptidase 27 (USP27) as a Cyclin E interactor. We found that USP27 promoted Cyclin E stability by negatively regulating its ubiquitination....
Autores principales: | Dong, Ling, Yu, Le, Bai, Chunrong, Liu, Liu, Long, Hua, Shi, Lei, Lin, Zhenghong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955865/ https://www.ncbi.nlm.nih.gov/pubmed/29497124 http://dx.doi.org/10.1038/s41388-018-0137-z |
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