Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations

Various experimental and computational techniques have been employed over the past decade to provide structural and thermodynamic insights into G Protein-Coupled Receptor (GPCR) dimerization. Here, we use multiple microsecond-long, coarse-grained, biased and unbiased molecular dynamics simulations (...

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Detalles Bibliográficos
Autores principales: Meral, Derya, Provasi, Davide, Prada-Gracia, Diego, Möller, Jan, Marino, Kristen, Lohse, Martin J., Filizola, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955887/
https://www.ncbi.nlm.nih.gov/pubmed/29769636
http://dx.doi.org/10.1038/s41598-018-26070-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955887/
https://www.ncbi.nlm.nih.gov/pubmed/29769636
http://dx.doi.org/10.1038/s41598-018-26070-8

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