Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

Furin cleavage of the HIV envelope glycoprotein is an essential step for cell entry that enables formation of well-folded, native-like glycosylated trimers, releases constraints on the fusion peptide, and limits enzymatic processing of the N-glycan shield. Here, we show that a cleavage-independent,...

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Detalles Bibliográficos
Autores principales: Sarkar, Anita, Bale, Shridhar, Behrens, Anna-Janina, Kumar, Sonu, Sharma, Shailendra Kumar, de Val, Natalia, Pallesen, Jesper, Irimia, Adriana, Diwanji, Devan C., Stanfield, Robyn L., Ward, Andrew B., Crispin, Max, Wyatt, Richard T., Wilson, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955915/
https://www.ncbi.nlm.nih.gov/pubmed/29769533
http://dx.doi.org/10.1038/s41467-018-04272-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955915/
https://www.ncbi.nlm.nih.gov/pubmed/29769533
http://dx.doi.org/10.1038/s41467-018-04272-y

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